n,n,n,n-tetramethylguanidinium acetate as an efficient and reusable ionic liquid catalyst for the one-pot synthesis of dihydropyrrol-2-ones

نویسندگان

seyed sajad sajadikhah

department of chemistry, payame noor university, iran

چکیده

an extremely facile and efficient procedure which has been developed for the synthesis of dihydropyrrol-2-ones. one-pot four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of n,n,n,n-tetramethylguanidinium acetate [tmg][ac] in methanol at ambient temperature provides substituted dihydropyrrol-2-ones in good to high yields. the important aspects of this multi-component heteroannulation are simple operations under mild conditions, readily available starting material and catalyst. furthermore, all products were obtained through a simple filtration and washed with ethanol and no need for column chromatography. it is found that the catalyst is recyclable and can be used up to four times without significant loss of its activity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

N,N,N,N-Tetramethylguanidinium acetate as an efficient and reusable ionic liquid catalyst for the one-pot synthesis of dihydropyrrol-2-ones

An extremely facile and efficient procedure which has been developed for the synthesis of dihydropyrrol-2-ones. One-pot four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of N,N,N,N-tetramethylguanidinium acetate [TMG][Ac] in methanol at ambient temperature provides substituted dihydropyrrol-2-ones in good to high yields. The important aspects of...

متن کامل

Ionic liquid-assisted synthesis of celexocib using tris-(2-hydroxyethyl) ammonium acetate as an efficient and reusable catalyst

Celecoxib is classified as none traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This compound has conventional properties of NSAIDs such as anti-inflammatory, analgesic, and antipyretic activities beside reduced risk of gastrointestinal side effect of traditional NSAIDs such as ibuprofen. This compound gets a second sale rank of NSAIDs market at 2016 in the world and sales more than ...

متن کامل

Ionic liquid-assisted synthesis of celexocib using tris-(2-hydroxyethyl) ammonium acetate as an efficient and reusable catalyst

Celecoxib is classified as none traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This compound has conventional properties of NSAIDs such as anti-inflammatory, analgesic, and antipyretic activities beside reduced risk of gastrointestinal side effect of traditional NSAIDs such as ibuprofen. This compound gets a second sale rank of NSAIDs market at 2016 in the world and sales more than ...

متن کامل

Montmorillonite modified as an efficient and environment friendly catalyst for one- pot synthesis of 3, 4-dihydropyrimidine-2(1H) ones

Montmorillonite modified is an efficient environmental friendly catalyst under one-pot-three-component synthesis of 3,4-dihydropyrimidine-2(1H) ones. The preparation was performed with an aldehyde, 1,3-dicarbonyl compounds, urea or thiourea under solvent-free conditions. In comparison with the other methods of Biginelli reaction, this new method has short reaction time inexpensive catalyst and ...

متن کامل

Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction

An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian chemical communication

جلد ۵، شماره Issue ۲. ۱۳۳-۲۶۷، صفحات ۱۳۳-۱۴۲

کلمات کلیدی
[ ' n ' , ' h e t e r o c y c l e ' , ' d i h y d r o p y r r o l ' , 2 , ' o n e ' , ' m u l t i ' , ' c o m p o n e n t r e a c t i o n ' , ' i o n i c l i q u i d ' , ' [ t m g ] [ a c ] ' , ' r e u s a b l e c a t a l y s t ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023